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Trumbull News Detail

Brasch Group Awarded NIH Grant to Study the Reactions of Vitamin B12 with Reactive Oxygen Species

Posted Oct. 14, 2011

The Brasch group in the Department of Chemistry and Biochemistry has been awarded $219 K from the National Institute of General Medical Sciences at the NIH to study the reactions of vitamin B12 with reactive oxygen species.  Elevated levels of reactive oxygen species are linked to numerous diseases associated with aging including cancer, neurodegenerative diseases, and cardiovascular disease.  A major intracellular form of vitamin B12, cob(II)alamin, is potentially capable of rapidly reacting with a range of reactive oxygen species, lowering reactive oxygen species concentrations.  Graduate student Rohan Dassanayake and undergraduate student Andrew Hunt will carry out kinetic and mechanistic studies on these reactions.  As part of this project, Rohan will travel to Brookhaven National Laboratory to carry out pulse radiolysis studies in the laboratory of Dr. Diane Cabelli, Department of Chemistry.

Rohan using stopped flow
Doctoral student Rohan Dassanayake will travel to Brookhaven National Laboratory
in New York to perform research as part of an NIH-sponsored project.